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Bioengineering

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JoVE Journal Bioengineering
Eine injizierbare and Drug belasteten supramolekulares Hydrogel für Lokale Catheter Injection in die Pig Herz
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Eine injizierbare and Drug belasteten supramolekulares Hydrogel für Lokale Catheter Injection in die Pig Herz

Article DOI: 10.3791/52450-v • 10:28 min • June 7th, 2015
June 7th, 2015 •
*1, *1, 2, 1, 2, 2, 2, 1
1Institute for Complex Molecular Systems, Department of Biomedical Engineering, Laboratory of Chemical Biology, Eindhoven University of Technology, 2Department of Cardiology, Division Heart and Lungs, Interuniversity Cardiology Institute of the Netherlands (ICIN), University Medical Center Utrecht
* These authors contributed equally

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Supramolekulare Hydrogelbildner basierend auf Ureido-Pyrimidinone ermöglicht volle Kontrolle über die makroskopischen Eigenschaften Gel und Sol-Gel-Schaltverhalten mit pH. Hier präsentieren wir ein Protokoll für die Formulierung und Einspritzen eines solchen supramolekularen Hydrogelbildner über ein Kathetersystem für die lokale Zustellung direkt in den relevanten Bereichen in der Schweineherz.

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Bioengineering Heft 100 supramolekulare Polymere Hydrogele Katheter-Injektion Medikamentenabgabe pH Schaltbarkeit Schweinemodell
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