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Evaluering af Zebrafisk nyrefunktion Ved hjælp af en fluorescerende Clearance Assay
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Evaluering af Zebrafisk nyrefunktion Ved hjælp af en fluorescerende Clearance Assay

Article DOI: 10.3791/52540-v • 08:13 min • February 20th, 2015
February 20th, 2015 •
1, 1, 2
1Genetics and Genomic Medicine, Institute of Child Health, University College London, 2Molecular Cell Science Research Centre, St. George's University of London

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Zebrafisken er et populært værktøj til at modellere kronisk nyresygdom (CKD). Deres lille størrelse gør det imidlertid umuligt at evaluere nyrefunktionen ved hjælp af traditionelle metoder. Vi beskriver et fluorescerende farvestof nyre clearance assay 1, der tillader kvantitativ analyse af zebrafisk nyrefunktion i CKD.

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Developmental Biology Nyre funktion, pronephric tubuli nyresygdom nyre clearance assay cilia Nephronophthisis. Kronisk nyresygdom Bardet Biedl syndrom perikardial injektion.
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