Mosaic Zebrafish Transgenesis for Functional Genomic Analysis of Candidate Cooperative Genes in Tumor Pathogenesis

Choong Yong Ung; Feng Guo; Xiaoling Zhang; Zhihui Zhu; Shizhen Zhu

doi:10.3791/52567

Journal

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Developmental Biology

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Tümör Patogenezinde Aday Kooperatif Genlerin Fonksiyonel Genomik Analizi Mozaik Zebra balığı Transgenesis

Mosaic Zebrafish Transgenesis for Functional Genomic Analysis of Candidate Cooperative Genes in Tumor Pathogenesis

JoVE Journal
Developmental Biology

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JoVE Journal Developmental Biology

Mosaic Zebrafish Transgenesis for Functional Genomic Analysis of Candidate Cooperative Genes in Tumor Pathogenesis

Tümör Patogenezinde Aday Kooperatif Genlerin Fonksiyonel Genomik Analizi Mozaik Zebra balığı Transgenesis

Please note that all translations are automatically generated. Click here for the English version.

11,068 Views

•

09:45 min

•

March 31, 2015

DOI:

10.3791/52567-v

DOI:

10.3791/52567-v

•

09:45 min

March 31, 2015

•

4 Views

Choong Yong Ung¹, Feng Guo², Xiaoling Zhang³, Zhihui Zhu³, Shizhen Zhu^1,3

¹Department of Molecular Pharmacology & Experimental Therapeutics,Mayo Clinic College of Medicine, Center for Individualized Medicine, ²Tufts University School of Medicine, ³Department of Biochemistry and Molecular Biology,Mayo Clinic

Summary

The goal of this study is to demonstrate how the mosaic transgenesis strategy can be used in zebrafish to rapidly and efficiently assess the relative contributions of multiple oncogenes in tumor initiation and progression in vivo.

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Tümör Patogenezinde Aday Kooperatif Genlerin Fonksiyonel Genomik Analizi Mozaik Zebra balığı Transgenesis

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Summary

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