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Iridium(III) Luminescent Probe for Detection of the Malarial Protein Biomarker Histidine Rich Protein-II
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Iridium(III) Luminescent Probe for Detection of the Malarial Protein Biomarker Histidine Rich Protein-II

Article DOI: 10.3791/52856 • 12:52 min • July 7th, 2015
July 7th, 2015 •
1, 1, 1, 1, 1
1Department of Chemistry, Vanderbilt University

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Robust detection reagents are of increasing necessity for developing new malaria diagnostic tools. An iridium(III) probe was designed that emits long-lasting luminescent signal in the presence of a histidine-rich malarial protein biomarker. Detection of the protein either in solution or immobilized on a magnetic particle affords flexibility in application.

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Iridium(III) Luminescent Probe Detection Malarial Protein Biomarker Histidine Rich Protein-II Synthesis Cyclometalated Ir(III) Complex Phosphorescent Signal Magnetic Particle Specificity Amino Acids Coordination Activity BNT-II Branched Peptide Mimic PfHRP-II Quenching Effects Steric Hindrance Triplet State Quenching Biolayer Interferometry Real-time Kinetics Limit Of Detection RcHRP-II Solution Immobilized Surface Magnetic Agarose Particle
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