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Realizando Permanente Distal Oriente cerebral com carótida comum Oclusão da Artéria em ratos idosos para estudar Cortical Isquemia com Deficiência Sustentada
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Realizando Permanente Distal Oriente cerebral com carótida comum Oclusão da Artéria em ratos idosos para estudar Cortical Isquemia com Deficiência Sustentada

Article DOI: 10.3791/53106-v • 09:11 min • February 23rd, 2016
February 23rd, 2016 •
*1,2, *1,2, 3, 1, 4, 4,5,6, 7, 2, 1
1Wolfson Centre for Age-Related Diseases, King's College London, University of London, 2Department of Neuroimaging, James Black Centre, Institute of Psychiatry, King's College London, University of London, 3Institute of Neuroscience and Psychology, Wellcome Surgical Institute, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, 4Research Service, Edward Hines Jr. VA Hospital, 5Neurology Service, Edward Hines Jr. VA Hospital, 6Department of Molecular Pharmacology and Therapeutics, Neuroscience Research Institute, Loyola University Chicago, 7Department of Oncology, The Gray Institute for Radiation, Oncology and Biology, University of Oxford
* These authors contributed equally

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Aqui apresentamos um protocolo para produzir oclusão média distal permanente da artéria cerebral em ratos fêmeas idosos com oclusão simultânea das artérias carótidas de gerar grandes infartos corticais e déficits sustentados. Mostramos confirmação do tamanho da lesão utilizando MRI estrutural às 24 h e 8 semanas após o acidente vascular cerebral.

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Medicina Edição 108 oclusão da artéria cerebral média Distal MCAO acidente vascular cerebral cirurgia isquemia cerebral os ratos idosos o déficit sustentado coagulação cálculos do tamanho da amostra
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