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Journal / Chemistry / Rakne Entropic Rate Akselerasjon indusert av…
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Chemistry

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Rakne Entropic Rate Akselerasjon indusert av Solvent Dynamics i Membrane Enzymer
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Rakne Entropic Rate Akselerasjon indusert av Solvent Dynamics i Membrane Enzymer

Article DOI: 10.3791/53168-v • 09:42 min • January 16th, 2016
January 16th, 2016 •
1, 1
1Science for Life Laboratory, School of Biotechnology, KTH Royal Institute of Technology

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Kanaler for transport av vannmolekyler i enzymer påvirker aktive sete solvatering og katalyse. Heri presenterer vi en protokoll for prosjektering av disse ekstra katalytiske motivene basert på in silico datamodellering og eksperimenter. Dette vil øke vår forståelse av påvirkning av løsemiddel dynamikk på enzymkatalyse.

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Kjemi Enzyme katalyse termodynamikk vann dynamikk membran protein kinetikk overgangstilstanden teori protein engineering hydrofobe effekten
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