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JoVE Journal
Bioengineering

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A Rapid and Quantitative Fluorimetric Method for Protein-Targeting Small Molecule Drug Screening
 
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A Rapid and Quantitative Fluorimetric Method for Protein-Targeting Small Molecule Drug Screening

Article doi: 10.3791/53261
October 16th, 2015

Summary October 16th, 2015

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A protocol for small molecular drug screening based on in-situ synthesis of ultrasmall fluorescent gold nanoclusters (Au NCs) using drug-loaded protein as template is presented. This method is simple to determine the binding affinity of drugs to a target protein by a visible fluorescent signal emitted from the protein-templated Au NCs.

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