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Using Micro-computed Tomography for the Assessment of Tumor Development and Follow-up of Response to Treatment in a Mouse Model of Lung Cancer
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Using Micro-computed Tomography for the Assessment of Tumor Development and Follow-up of Response to Treatment in a Mouse Model of Lung Cancer

Article DOI: 10.3791/53904-v • 11:31 min • May 20th, 2016
May 20th, 2016 •
1, 1, 1, 1, 2, 2, 1
1Division of Pulmonary Medicine, Keio University School of Medicine, 2Department of Developmental Biology, Washington University School of Medicine

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We describe a method for the detection of tumor nodule development in the lungs of an adenocarcinoma mouse model using micro-computed tomography and its use for monitoring changes in nodule size over time and in response to treatment. The accuracy of the assessment was confirmed with end-point histological quantification.

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Micro-computed Tomography Assessment Tumor Development Treatment Response Mouse Model Lung Cancer Advantages Experiments Key Questions Growth Rate Therapeutic Interventions Technique Time-saving Effort-saving Mice Per Study Group Scanner Control Software Package Warm-up Cycle Sample Bed Anesthetize Isoflurane Skin Pinch Ophthalmic Ointment
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