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LC-MS Analisi delle piastrine umane come una piattaforma per lo Studio del metabolismo mitocondriale
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LC-MS Analisi delle piastrine umane come una piattaforma per lo Studio del metabolismo mitocondriale

Article DOI: 10.3791/53941-v • 06:04 min • April 4th, 2016
April 4th, 2016 •
*1,2, *2,3, 1,2, 2,3, 2,3, 4, 4, 1,2, 5, 1,2
1Center for Cancer Pharmacology, University of Pennsylvania, 2Center for Excellence in Environmental Toxicology, University of Pennsylvania, 3Penn SRP and Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, 4Division of Traumatology, Department of Surgery, Critical Care and Acute Care Surgery, University of Pennsylvania, 5A.J. Drexel Autism Institute, Drexel University
* These authors contributed equally

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Qui mostriamo isolato piastrine umane possono essere utilizzati come accessibili ex vivo modello per studiare adattamenti metabolici in risposta al complesso I inibitore rotenone. Questo approccio impiega tracing isotopica e relativa quantificazione dal liquido spettrometria cromatografia massa e può essere applicato ad una varietà di disegni di studio.

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Scienze ambientali metabolismo traccianti isotopici piastrine la spettrometria di massa i mitocondri rotenone xenobiotici
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