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Gap Junctional Intercellular Communication
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Gap Junctional Intercellular Communication: A Functional Biomarker to Assess Adverse Effects of Toxicants and Toxins, and Health Benefits of Natural Products

Article DOI: 10.3791/54281-v • 05:27 min • December 25th, 2016
December 25th, 2016 •
1, 2, 2
1Department of Pediatrics & Human Development, Institute for Integrative Toxicology, Michigan State University, 2RECETOX — Research Centre for Toxic Compounds in the Environment, Faculty of Science, Masaryk University

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Summary
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This protocol describes a scalpel loading-fluorescent dye transfer technique that measures intercellular communication through gap junction channels. Gap junctional intercellular communication is a major cellular process by which tissue homeostasis is maintained and disruption of this cell signaling has adverse health effects.

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Gap Junctional Intercellular Communication Biomarker Adverse Effects Toxicants Toxins Health Benefits Natural Products Assay Pharmacological Needs Toxicological Needs Compound Development Tissue Development Gap Junction Function Population Of Cells WB-F344 Rat Liver Epithelial Cells Culture Plates Experimental Treatment Dose-response Experiments Phenanthrene Acetonitrile
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