Waiting
Login processing...

Trial ends in Request Full Access Tell Your Colleague About Jove
Journal / Biochemistry / Methode voor het identificeren van…
JoVE Journal
Biochemistry

A subscription to JoVE is required to view this content.

JoVE Journal Biochemistry
Methode voor het identificeren van kleinmoleculige remmers van het eiwit-eiwit interactie tussen HCN1 en TRIP8b
Growing Protein Crystals with Distinct Dimensions Using Automated Crystallization Coupled with In Situ Dynamic Light Scattering
Journal (Biochemistry)
Growing Protein Crystals with Distinct Dimensions Using Automated Crystallization Coupled with In Situ Dynamic Light Scattering
High-Pressure NMR Experiments for Detecting Protein Low-Lying Conformational States
Journal (Biochemistry)
High-Pressure NMR Experiments for Detecting Protein Low-Lying Conformational States
 
Click here for the English version

Methode voor het identificeren van kleinmoleculige remmers van het eiwit-eiwit interactie tussen HCN1 en TRIP8b

Article DOI: 10.3791/54540-v • 10:20 min • November 11th, 2016
November 11th, 2016 •
*1, *1, 2, 3, 1, 1, 4, 1,5
1Davee Department of Neurology and Clinical Neurosciences, Feinberg School of Medicine, Northwestern University, 2Center for Molecular Innovation and Drug Discovery, Northwestern University, 3Department of Pharmacology, Feinberg School of Medicine, Northwestern University, 4High Throughput Analysis Laboratory, Department of Molecular Biosciences, Northwestern University, 5Department of Physiology, Feinberg School of Medicine, Northwestern University
* These authors contributed equally

Chapters

Summary
Automatic Translation

Please note that all translations are automatically generated.

Click here for the English version.

De interactie tussen HCN kanalen en hun ondersteunende subunit is geïdentificeerd als een therapeutisch doel in depressieve stoornis. Hier wordt een fluorescentie-polarisatie- methode voor het identificeren van kleinmoleculige remmers van dit eiwit-eiwit interactie, gepresenteerd.

Tags

Biochemistry High-throughput screening drug discovery eiwit-eiwit interacties fluorescentiepolarisatie HCN TRIP8b
Read Article

Get cutting-edge science videos from JoVE sent straight to your inbox every month.

Waiting X
Simple Hit Counter