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Journal / Biochemistry / 방법 및 HCN1 TRIP8b 간의 단백질 - 단백질 상호 작용의 작은 분자 억제제…
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Biochemistry

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JoVE Journal Biochemistry
방법 및 HCN1 TRIP8b 간의 단백질 - 단백질 상호 작용의 작은 분자 억제제 식별
Determining if DNA Stained with a Cyanine Dye Can Be Digested with Restriction Enzymes
Journal (Biochemistry)
Determining if DNA Stained with a Cyanine Dye Can Be Digested with Restriction Enzymes
Transverse Sectioning of Mature Rice (Oryza sativa L.) Kernels for Scanning Electron Microscopy Imaging Using Pipette Tips as Immobilization Support
Journal (Biochemistry)
Transverse Sectioning of Mature Rice (Oryza sativa L.) Kernels for Scanning Electron Microscopy Imaging Using Pipette Tips as Immobilization Support
 
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방법 및 HCN1 TRIP8b 간의 단백질 - 단백질 상호 작용의 작은 분자 억제제 식별

Article DOI: 10.3791/54540-v • 10:20 min • November 11th, 2016
November 11th, 2016 •
*1, *1, 2, 3, 1, 1, 4, 1,5
1Davee Department of Neurology and Clinical Neurosciences, Feinberg School of Medicine, Northwestern University, 2Center for Molecular Innovation and Drug Discovery, Northwestern University, 3Department of Pharmacology, Feinberg School of Medicine, Northwestern University, 4High Throughput Analysis Laboratory, Department of Molecular Biosciences, Northwestern University, 5Department of Physiology, Feinberg School of Medicine, Northwestern University
* These authors contributed equally

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HCN 채널과 보조 서브 유닛 사이의 상호 작용은 주요 우울 장애의 치료 대상으로 확인되었습니다. 여기서,이 단백질 - 단백질 상호 작용의 소분자 억제제를 식별하기위한 형광 편광 - 기반 방법이 제공된다.

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생화학 문제 117 높은 처리량 검사 신약 개발 단백질 - 단백질 상호 작용 형광 편광 HCN TRIP8b
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