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A High Throughput, multiplexée et ciblée protéomique CSF Assay à Quantifier neurodégénératifs Biomarqueurs et apolipoprotéine E isoformes Status
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A High Throughput, multiplexée et ciblée protéomique CSF Assay à Quantifier neurodégénératifs Biomarqueurs et apolipoprotéine E isoformes Status

Article DOI: 10.3791/54541-v • 07:08 min • October 20th, 2016
October 20th, 2016 •
*1, *1, 1, 1, 2, 3, 4, 5, 1
1Centre for Translational Omics, Genetics and Genomic Medicine Deptartment, Great Ormond Street Institute of Child Health, University College London, 2Dementia Research Centre, Institute of Neurology, University College London, 3Clinical Neurochemistry Laboratory, Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy, University of Gothenburg, 4Neurology Unit, Department of Pathophysiology and Transplantation, University of Milan, 5Great Ormond Street Hospital for Children, University College London
* These authors contributed equally

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Nous décrivons un haut-débit, multiplex, et le liquide céphalorachidien protéomique ciblée (CSF) test développé avec le potentiel pour la traduction clinique. Le test peut quantifier des marqueurs potentiels et les facteurs de risque pour la neurodégénérescence, telles que les variantes de l'apolipoprotéine E (E2, E3 et E4), et mesurer leur expression allélique.

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Médecine numéro 116 CSF protéomique ciblées surveillance multiple de réaction l'apolipoprotéine E isoforme la démence biomarqueur spectrométrie de masse tandem multiplex
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