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Journal / Medicine / 高通量，复用和有针对性的蛋白质组学分析脑脊液量化神经退行性生物标志物和载脂蛋白E亚型状态…
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高通量，复用和有针对性的蛋白质组学分析脑脊液量化神经退行性生物标志物和载脂蛋白E亚型状态
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高通量，复用和有针对性的蛋白质组学分析脑脊液量化神经退行性生物标志物和载脂蛋白E亚型状态

Article DOI: 10.3791/54541-v • 07:08 min • October 20th, 2016
October 20th, 2016 •
*1, *1, 1, 1, 2, 3, 4, 5, 1
1Centre for Translational Omics, Genetics and Genomic Medicine Deptartment, Great Ormond Street Institute of Child Health, University College London, 2Dementia Research Centre, Institute of Neurology, University College London, 3Clinical Neurochemistry Laboratory, Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy, University of Gothenburg, 4Neurology Unit, Department of Pathophysiology and Transplantation, University of Milan, 5Great Ormond Street Hospital for Children, University College London
* These authors contributed equally

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我们描述了一种高通量，多重，和有针对性的蛋白质组学脑脊液（CSF）试验与临床翻译潜在发展。该试验可定量潜在标记和危险因素的神经变性，如载脂蛋白E的变体（E2，E3和E4），并测量它们的等位基因的表达。

Tags

医药，116期，CSF，有针对性的蛋白质组学，多反应监测，载脂蛋白E亚型，老年痴呆症，生物标记物，串联质谱，多路
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