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JoVE Journal Medicine
Longitudinal
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Longitudinal

Article DOI: 10.3791/54796-v • 07:47 min • December 6th, 2016
December 6th, 2016 •
1,2,3, 1,2,3, 1,2,3, 1,2,3, 1,2,3
1Inserm, U1191, Institute of Functional Genomics, 2CNRS, UMR-5203, 3Université de Montpellier

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Dette håndskrift beskrives en procedure til at spore ombygning af cerebrovasculature under amyloid plaque akkumulation in vivo ved anvendelse langsgående to-foton mikroskopi. En tyndet-kranium præparat muliggør visualisering af fluorescerende farvestoffer til at vurdere progressionen af ​​cerebrovaskulær skade i en musemodel for Alzheimers sygdom.

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Medicin neurovidenskab to-foton laser mikroskopi neurovaskulære plasticitet amyloid aflejringer tyndet-kranium Alzheimers sygdom
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