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Journal / Genetics / 工程人为因素来特异性地操纵人细胞中的选择性剪接…
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Genetics

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工程人为因素来特异性地操纵人细胞中的选择性剪接

Article DOI: 10.3791/54967-v • 10:06 min • April 26th, 2017
April 26th, 2017 •
*1, *1, 2, 1, 1, 1, 1
1Key Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences (SIBS), 2Institute of Cancer Stem Cell, Second Affiliated Hospital, Cancer Center, Dalian Medical University
* These authors contributed equally

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该报告介绍了一种生物工程方法来设计和构建特异性调节在哺乳动物细胞中靶基因的剪接新颖人工剪接因子（ASFS）。该方法可以进一步扩展来设计各种人为因素来操纵RNA代谢的其它方面。

Tags

遗传学，第122，人工RNA结合因子，蛋白质工程，剪接因子，可变剪接，PUF支架，RNA结合蛋白，癌
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