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JoVE Journal Genetics
Tekniske kunstige faktorer til specifikt manipulation af alternativ splejsning i humane celler
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Tekniske kunstige faktorer til specifikt manipulation af alternativ splejsning i humane celler

Article DOI: 10.3791/54967-v • 10:06 min • April 26th, 2017
April 26th, 2017 •
*1, *1, 2, 1, 1, 1, 1
1Key Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences (SIBS), 2Institute of Cancer Stem Cell, Second Affiliated Hospital, Cancer Center, Dalian Medical University
* These authors contributed equally

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Denne rapport beskriver en naturnær metode til at designe og konstruere hidtil ukendte Kunstige splejsningsfaktorer (ASFS), som specifikt modulerer splejsning af målgener i pattedyrceller. Denne fremgangsmåde kan udvides yderligere til at konstruere forskellige kunstige faktorer at manipulere andre aspekter af RNA metabolisme.

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Genetik kunstige RNA bindende faktorer protein engineering splejsningsfaktorer alternativ splejsning PUF scaffold RNA-bindende proteiner kræft
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