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JoVE Journal Cancer Research
A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies
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A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies

Article DOI: 10.3791/55080-v • 06:38 min • April 12th, 2017
April 12th, 2017 •
*1,2, *1,2,3, 4,5, 1,2,3
1Department of Urology, University of Minnesota, 2Masonic Cancer Center, University of Minnesota, 3Microbiology, Immunology, and Cancer Biology Graduate Program, University of Minnesota, 4Department of Medical Microbiology, Immunology and Cell Biology, Southern Illinois University School of Medicine, 5Simmons Cancer Institute
* These authors contributed equally

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Summary
Automatic Translation

Implementation of an orthotopic model of renal cell carcinoma in immunocompetent mice affords the investigator a clinically-relevant system defined by the presence of a primary renal tumor and lung metastases in the same animal. This system can be used to preclinically test a variety of treatments in vivo.

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Syngeneic Mouse Model Metastatic Renal Cell Carcinoma Preclinical Therapies Orthotopic Renal Tumors Tumor Growth Metastasis Anti-tumor Therapies Urologic Oncology Kidney Cancer Intrarenal Tumor Implantation Lung Metastasizing Renal Tumor Renca Tumor Cells Trypsin HBSS RPMI Medium Syringe Sedation Level Confirmation Vet Ointment Povidone Iodine Antiseptic Sterile Scalpel
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