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Journal / Immunology and Infection / Küçük moleküllerin yüksek verimli tarama için…
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Immunology and Infection

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JoVE Journal Immunology and Infection
Küçük moleküllerin yüksek verimli tarama için uygun bir floresan bazlı lenfositi analizi
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Küçük moleküllerin yüksek verimli tarama için uygun bir floresan bazlı lenfositi analizi

Article DOI: 10.3791/55199-v • 08:43 min • March 10th, 2017
March 10th, 2017 •
1, 2, 2, 2, 1,2,3
1Department of Microbiology, Infectiology and Immunology, Université de Montréal, 2Department of Pharmacology and Physiology, Université de Montréal, 3Molecular Biology Program, Université de Montréal

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Biz bu çalışmada bir transgenik fareden türetilen lenfositlerin kullanılarak yeni floresans bazlı analiz sunuyoruz. Bu deney, inhibe veya lenfosit aktivasyonunu teşvik ya kapasitesine sahip küçük moleküller, yüksek verimli tarama (HTS) için uygundur.

Tags

Immunology Sayı 121 yüksek verimli tarama fenotipik tarama hedef bazlı tarama ilaç keşfi lenfosit T hücreleri B hücreleri floresan yeşil flüoresan proteini Nur77 immünosupresyon aktivasyon
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