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Murine Aortic Crush Injury

Murine Aortic Crush Injury: An Efficient In Vivo Model of Smooth Muscle Cell Proliferation and Endothelial Function

Article DOI: 10.3791/55201 06:14 min June 11th, 2017
June 11th, 2017



Restenosis following cardiovascular procedures (bypass surgery, angioplasty, or stenting) is a significant problem reducing the durability of these procedures. An ideal therapy would inhibit smooth muscle cell (VSMC) proliferation while promoting regeneration of the endothelium. We describe a model for simultaneous assessment of VSMC proliferation and endothelial function in vivo.



Murine Aortic Crush Injury In Vivo Model Smooth Muscle Cell Proliferation Endothelial Function Restenosis Vascular Interventions Vascular Biology Reendothelialization Animal Model Key Questions Procedure Assessment Post Doctoral Fellow Laboratory Anesthetized C57BL/6 Mouse Ventral Abdomen Sternum Inguinal Region Disinfect Shoulder Area Analgesia Supine Position Surgical Tray Isothermal Pad Surgical Sight Betadine Chlorhexidine Alcohol Rinse Ointment Eyes Abdominal Laparotomy Incision
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