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Genetics

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JoVE Journal Genetics
Genoom bewerken en Directed Differentiatie van hPSCs voor ondervragen Lineage Determinanten in Human eilandjes Development
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Genoom bewerken en Directed Differentiatie van hPSCs voor ondervragen Lineage Determinanten in Human eilandjes Development

Article DOI: 10.3791/55267-v • 09:37 min • March 5th, 2017
March 5th, 2017 •
*1, *1, *1, 1
1Developmental Biology Program, Sloan Kettering Institute
* These authors contributed equally

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Protocollen bij HPSC mutant lijnen met behulp van de iCRISPR platform te genereren en om hPSCs in glucose-responsief β-achtige cellen te onderscheiden zijn beschreven. De combinatie van genoom editing-technologie met HPSC gerichte differentiatie biedt een krachtig platform voor de systematische analyse van de rol van de lijn determinanten in de menselijke ontwikkeling en de progressie van de ziekte.

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Genetics CRISPR / Cas9 iCas9 genoom bewerken AAVS1 menselijke pluripotente stamcellen pancreas differentiatie glucose-responsief β-achtige cellen diabetes
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