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Journal / Medicine / Bestemmelse af den Relative potens af en Anti-TNF …
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JoVE Journal Medicine
Bestemmelse af den Relative potens af en Anti-TNF monoklonale antistof (mAb) af Neutralizing TNF ved hjælp af en In Vitro bioanalytisk metode
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Bestemmelse af den Relative potens af en Anti-TNF monoklonale antistof (mAb) af Neutralizing TNF ved hjælp af en In Vitro bioanalytisk metode

Article DOI: 10.3791/55376-v • 16:07 min • September 16th, 2017
September 16th, 2017 •
1, 1, 1, 1, 1, 2
1Research and Development, Probiomed, 2Bioprocess Research and Development Unit, Instituto Politecnico Nacional

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En protokol til bestemmelse af relativ anti-apoptotiske aktiviteten af en anti-TNFα mAb ved hjælp af en neutralisering mekanisme med WEHI 164 celler er præsenteret her. Denne protokol er nyttig til sammenligning neutralisering styrken af forskellige molekyler med den samme biologiske funktioner.

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Medicin sag 127 apoptose neutralisering assay tumor nekrose faktor alfa anti-TNFα mAb biocomparability
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