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Generalized Psychophysiological Interaction (PPI) Analysis of Memory Related Connectivity in Individuals at Genetic Risk for Alzheimer's Disease

Article DOI: 10.3791/55394-v • 09:38 min • November 14th, 2017
November 14th, 2017 •
1, 2, 1, 1, 1
1Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, 2Biospective, Inc.

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This manuscript describes how to implement a psychophysiological interaction analysis to reveal task-dependent changes in functional connectivity between a selected seed region and voxels in other regions of the brain. Psychophysiological interaction analysis is a popular method to examine task effects on brain connectivity, distinct from traditional univariate activation effects.

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Generalized Psychophysiological Interaction (PPI) Analysis Memory-related Connectivity Individuals Genetic Risk Alzheimer's Disease Functional Connectivity Hippocampus Cognitive Neuroscience Cognitive Demands Experimental Task Technique Hypotheses Brain Regions Cognitive Task Experiment Aged 55 And Older Cognitive Decline Genotyped Apolipoprotein E Epsilon Four Allele MRI Safety Screening Informed Consent Three-tesla MRI System Whole Brain Imaging Data Functional Imaging Echo-planar Imaging Sequence Unrelated Words-associative Memory Task Registration Of Functional Images T2-weighted Coplanar Structural Images High-resolution Structural Imaging 3D T1-weighted Sequence Preprocessing Steps
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