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JoVE Journal Bioengineering
Automatisert Sammentrekning Analysis of Human Engineered hjertevev for Cardiac Drug Safety Screening
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Automatisert Sammentrekning Analysis of Human Engineered hjertevev for Cardiac Drug Safety Screening

Article DOI: 10.3791/55461-v • 10:39 min • April 15th, 2017
April 15th, 2017 •
1, 1, 1, 1, 1, 1, 1
1Department of Experimental Pharmacology and Toxicology, Cardiovascular Research Center, University Medical Center Hamburg-Eppendorf and DZHK (German Center for Cardiovascular Research)

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Her viser vi generering av human konstruert hjertevev fra induserte pluripotente stamceller (hiPSC) -avledede kardiomyocytter. Vi presenterer en metode for å analysere kontraksjonskraft og eksempelvise endring av sammentrekning mønster av hERG kanal inhibitor E-4031. Denne fremgangsmåten viser høy grad av robusthet og egnethet for hjertelegemiddelscreening.

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Bioteknologi Engineered hjertet vev cardiomyocytes tissue engineering hjertestans differensiering narkotika sikkerhet farmakologi
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