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JoVE Journal Neuroscience
Bioluminescens Billeddannelse af Neuroinflammation i transgene mus efter perifer Inokulering af alfa-synuclein Fibriller
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Bioluminescens Billeddannelse af Neuroinflammation i transgene mus efter perifer Inokulering af alfa-synuclein Fibriller

Article DOI: 10.3791/55503-v • 09:32 min • April 13th, 2017
April 13th, 2017 •
1, 1, 1, 2, 2, 1
1German Center for Neurodegenerative Diseases (DZNE), 2Centre for Prions and Protein Folding Diseases & Department of Biochemistry, University of Alberta

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Perifer injektion af alfa-synuclein fibriller i peritoneum eller tunge af Tg (M83 +/-: GFAP -Luc +/-) mus, som udtrykker humant alfa-synuclein med familiær A53T mutation og ildflueluciferase, kan inducere neuropatologi, herunder neuroinflammation , i det centrale nervesystem.

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Neuroscience Alpha-synuclein bioluminescens billeddannelse inflammation synukleinopatien neuroinvasion Parkinsons sygdom perifer prion-lignende prionoid
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