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JoVE Journal Neuroscience
Biolumineszenz-Bildgebung von Neuroinflammation in transgenen Mäusen nach peripherer Inokulation von Alpha-Synuclein
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Biolumineszenz-Bildgebung von Neuroinflammation in transgenen Mäusen nach peripherer Inokulation von Alpha-Synuclein

Article DOI: 10.3791/55503-v • 09:32 min • April 13th, 2017
April 13th, 2017 •
1, 1, 1, 2, 2, 1
1German Center for Neurodegenerative Diseases (DZNE), 2Centre for Prions and Protein Folding Diseases & Department of Biochemistry, University of Alberta

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Periphere Injektion von alpha-Synuclein - Fibrillen in das Peritoneum oder die Zunge von Tg (M83 +/-: GFAP -Luc +/-) Mäuse, der humanen alpha-Synuclein mit der familial A53T - Mutation exprimieren und Glühwürmchen - Luciferase kann Neuropathologie, einschließlich neuroinflammation induziert in ihrem Zentralnervensystem.

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Neuroscience Ausgabe 122 Alpha-Synuclein Biolumineszenz-Bildgebung Entzündungen synucleinopathy Neuroinvasion Parkinson-Krankheit periphere Prion-like prionoid
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