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Bioluminescence avbildning av Neuroinflammation i transgena möss efter perifer ympning av alfa-synuklein fibriller
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Bioluminescence avbildning av Neuroinflammation i transgena möss efter perifer ympning av alfa-synuklein fibriller

Article DOI: 10.3791/55503-v • 09:32 min • April 13th, 2017
April 13th, 2017 •
1, 1, 1, 2, 2, 1
1German Center for Neurodegenerative Diseases (DZNE), 2Centre for Prions and Protein Folding Diseases & Department of Biochemistry, University of Alberta

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Perifer injektion av alfa-synuklein fibriller in i bukhinnan eller tunga av Tg (M83 +/-: GFAP -luc +/-) möss, vilka uttrycker humant alfa-synuklein med familjär A53T mutation och eldflugeluciferas, kan inducera neuropatologi, inklusive neuroinflammation , i deras centrala nervsystemet.

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Neuroscience Alpha-synuklein mareld imaging inflammation synukleinopatin neuroinvasion Parkinsons sjukdom perifer prion-liknande prionoid
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