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Journal / Immunology and Infection / In vitro- metoder for sammenligning av målbinding …
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Immunology and Infection

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JoVE Journal Immunology and Infection
In vitro- metoder for sammenligning av målbinding og CDC-induksjon mellom terapeutiske antistoffer
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In vitro- metoder for sammenligning av målbinding og CDC-induksjon mellom terapeutiske antistoffer: applikasjoner i biosimilaritetsanalyse

Article DOI: 10.3791/55542-v • 07:25 min • May 4th, 2017
May 4th, 2017 •
1,2, 1, 3, 4,5, 6
1Unit for Development and Research in Bioprocesses Unit (UDIBI), National School of Biological Sciences, National Polytechnic Institute (IPN), University of Mexico (UNAM), 2School of Chemistry, National Autonomous University of Mexico (UNAM), 3Graduate Program in Chemical Sciences, National Autonomous University of Mexico (UNAM), 4Unit for Development Research and Medical Innovation in Biotechnology (UDIMEB), National School of Biological Sciences, National Polytechnic Institute (IPN), 5Department of Immunology, National Scool of Biological Sciences, National Polytechnic Institute (IPN), 6Department of Pharmacology and Unit of Translational Biomedicine (CMN 20 de noviembre), School of Medicine, National Autonomous University of Mexico (UNAM)

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Denne protokollen beskriver in vitro-sammenligning av to viktige funksjonelle egenskaper rituximab: målbindingsdomene og komplementavhengig cytotoksisitet (CDC) induksjon. Metodene som ble benyttet for en side-til-side-sammenligning mellom referanse rituximab rituximab og en biosimilar. Disse analyser kan anvendes under biosimilar utvikling eller som en kvalitetskontroll i sin produksjon.

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Immunology utgave 123 Rituximab biosimilar anti-CD20 terapeutisk mAb CDC strømningscytometri Daudi-celler
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