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Neuroscience

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JoVE Journal Neuroscience
Anatomisk inspirerede tredimensionale mikrovæv-konstruerede neurale netværk til nervesystem rekonstruktion, modulering og modellering
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Anatomisk inspirerede tredimensionale mikrovæv-konstruerede neurale netværk til nervesystem rekonstruktion, modulering og modellering

Article DOI: 10.3791/55609-v • 10:45 min • May 31st, 2017
May 31st, 2017 •
*1,2,3, *1,2,3, 1,2,3, 2,3, 2,3, 2,3,4, 2,3, 2,3, 2,3
1Department of Bioengineering, School of Engineering and Applied Science, University of Pennsylvania, 2Center for Brain Injury & Repair, Department of Neurosurgery, Perelman School of Medicine, University of Pennsylvania, 3Center for Neurotrauma, Neurodegeneration & Restoration, Michael J. Crescenz Veterans Affairs Medical Center, 4School of Biomedical Engineering, Drexel University
* These authors contributed equally

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Dette manuskript beskriver fremstillingen af ​​mikrovæv-manipulerede neurale netværk: tredimensionale mikronstørrelseskonstruktioner bestående af langjusterede aksonale kanaler, der spænder over aggregerede neuronal populationer indkapslet i en rørformet hydrogel. Disse levende stilladser kan fungere som funktionelle relæer til rekonstruktion eller modulering af neurale kredsløb eller som biofideliske test-senge, der efterligner grå-hvid stof neuroanatomi.

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Neurovidenskab udgave 123 neurale vævsteknologi biomaterialer levende stilladser neurotrauma neuroregeneration neuromodulation axonale veje synapser
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