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Journal / Bioengineering / Tessutale tridimensionale allineato Astrocyte…
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Bioengineering

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JoVE Journal Bioengineering
Tessutale tridimensionale allineato Astrocyte reti per ricapitolare i meccanismi dello sviluppo e facilitare la rigenerazione del sistema nervoso
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Tessutale tridimensionale allineato Astrocyte reti per ricapitolare i meccanismi dello sviluppo e facilitare la rigenerazione del sistema nervoso

Article DOI: 10.3791/55848-v • 08:56 min • January 10th, 2018
January 10th, 2018 •
*1,2,3, *1,2,4, 1,2,4, 1,2, 1,5, 1,5, 1,2,4, 1,2,5
1Center for Brain Injury & Repair, Department of Neurosurgery, Perelman School of Medicine, University of Pennsylvania, 2Center for Neurotrauma, Neurodegeneration & Restoration, Michael J. Crescenz Veterans Affairs Medical Center, 3School of Biomedical Engineering, Drexel University, 4Department of Bioengineering, School of Engineering and Applied Sciences, University of Pennsylvania, 5Neuroscience Graduate Group, Perelman School of Medicine, University of Pennsylvania
* These authors contributed equally

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Presenteremo lo sviluppo di auto-assemblati, tridimensionale fasci di somata astrocytic allineati longitudinalmente e processi all'interno di un encasement romanzo biomateriale. Questi ingegnerizzato "ponteggi vivente", che esibiscono micron-scala diametro ancora estendere centimetri di lunghezza, può servire come banchi di prova per lo studio dei meccanismi dello sviluppo neurologico o facilitare la neurorigenerazione di regia della migrazione neuronale e/o assonale path-finding.

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Bioingegneria problema 131 tessuto neurale ingegneria vivente impalcature neurotrauma neurorigenerazione migrazione cellulare path-finding assone reti di astrociti cellule staminali neurali
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