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Chapters
- 00:05Title
- 01:05Intranasal Infection
- 01:49Characterization of Viral Pathogenesis
- 05:29Homogenization of Lungs and Nasal Mucosa and Virus Tritation by Indirect Immunofluorescence
- 08:30Results: Viral Pathogenesis and Humoral Responses in Influenza A Virus Infected Mice
- 10:03Conclusion
Influenza A viruses (IAVs) are important human respiratory pathogens. To understand the pathogenicity of IAVs and to perform preclinical testing of novel vaccine approaches, animal models mimicking human physiology are required. Here, we describe techniques to evaluate IAV pathogenesis, humoral responses and vaccine efficacy using a mouse model of infection.
