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JoVE Journal Neuroscience
Eksperimentelle modeller til undersøgelse af neuroprotektion af sur postkonditionering mod cerebral iskæmi
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Eksperimentelle modeller til undersøgelse af neuroprotektion af sur postkonditionering mod cerebral iskæmi

Article DOI: 10.3791/55931-v • 10:13 min • July 31st, 2017
July 31st, 2017 •
*1, *1, 1, 1, 1, 1, 1
1Institute of Pharmacology & Toxicology, College of Pharmaceutical Sciences, Department of Pharmacology, Key Laboratory of Medical Neurobiology of The Ministry of Health of China, Zhejiang Province Key Laboratory of Neurobiology, Zhejiang University
* These authors contributed equally

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Acid postkonditionering beskytter mod cerebral iskæmi. Her præsenterer vi to modeller til at udføre APC. De opnås henholdsvis ved at overføre kortikostriatale skiver til sur buffer efter oxygen-glucose-deprivation in vitro og ved at inhalere 20% CO 2 efter midter cerebral arterieeklusion i vivo .

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Neurobiologi udgave 125 cerebral iskæmi sur postkonditionering kortikostriatal skive ilt-glucose deprivation midter cerebral arterie okklusion (MCAO) hjerneinfarkt volumen tidsvindue
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