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Immunology and Infection

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JoVE Journal Immunology and Infection
Generation av Escape varianter av neutraliserande influensa Virus monoklonala antikroppar
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Generation av Escape varianter av neutraliserande influensa Virus monoklonala antikroppar

Article DOI: 10.3791/56067-v • 07:55 min • August 29th, 2017
August 29th, 2017 •
1,2, 1,2, 1,2, 1,2, 3, 3, 1, 1
1Department of Microbiology, Icahn School of Medicine at Mount Sinai, 2Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, 3The Department of Medicine, Section of Rheumatology, The Knapp Center for Lupus and Immunology Research, The University of Chicago

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Vi beskriver en metod genom vilken vi identifiera kritiska restsubstanser krävs för bindning av mänskliga eller murina monoklonala antikroppar som är riktade till den virala hemagglutinin av influensa A virus. Protokollet kan anpassas till andra virus ytan glykoproteiner och deras motsvarande neutraliserande antikroppar.

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Immunologi fråga 126 influensavirus monoklonala antikroppar fly varianter mikrobiologi virologi
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