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Immunology and Infection

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JoVE Journal Immunology and Infection
Generation af undslippe varianter af neutraliserende Influenza Virus monoklonale antistoffer
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Generation af undslippe varianter af neutraliserende Influenza Virus monoklonale antistoffer

Article DOI: 10.3791/56067-v • 07:55 min • August 29th, 2017
August 29th, 2017 •
1,2, 1,2, 1,2, 1,2, 3, 3, 1, 1
1Department of Microbiology, Icahn School of Medicine at Mount Sinai, 2Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, 3The Department of Medicine, Section of Rheumatology, The Knapp Center for Lupus and Immunology Research, The University of Chicago

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Vi beskriver en metode, hvormed vi identificere kritiske restkoncentrationer kræves for bindingen af menneskelige eller murine monoklonale antistoffer, der er målrettet den virale hemagglutinin af influenza A virus. Protokollen kan tilpasses til andre virus overflade glykoproteiner og deres tilsvarende neutraliserende antistoffer.

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Immunologi sag 126 Influenza-virus monoklonale antistoffer undslippe varianter mikrobiologi virologi
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