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Screening delle nanoparticelle bioattive in cellule immunitarie fagocitiche per gli inibitori della segnalazione di ricetrasmettitori simili
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Screening delle nanoparticelle bioattive in cellule immunitarie fagocitiche per gli inibitori della segnalazione di ricetrasmettitori simili

Article DOI: 10.3791/56075-v • 09:51 min • July 26th, 2017
July 26th, 2017 •
1, 2, 1, 1, 2
1Department of Respiratory Medicine, Shanghai First People's Hospital, Shanghai Jiaotong University School of Medicine, 2Department of Pediatrics, BC Children's Hospital and University of British Columbia

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La segnalazione di TLR (Toll-like receptor) ha un ruolo importante nella fisiopatologia di molte malattie infiammatorie umane e la regolazione delle risposte TLR mediante nanoparticelle bioattive è prevista per essere vantaggiosa in molte condizioni infiammatorie. Le cellule reporter THP-1 forniscono una piattaforma di screening versatile e robusta per identificare nuovi inibitori della segnalazione TLR.

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Medicina Numero 125 Nanoparticelle bioattive screening nanodrug nanoparticelle d'oro peptide ricadente come il toll-like inibitore TLR cellule reporter
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