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Screening af bioaktive nanopartikler i phagocytiske immunceller til inhibitorer af Toll-lignende Receptor Signalering
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Screening af bioaktive nanopartikler i phagocytiske immunceller til inhibitorer af Toll-lignende Receptor Signalering

Article DOI: 10.3791/56075-v • 09:51 min • July 26th, 2017
July 26th, 2017 •
1, 2, 1, 1, 2
1Department of Respiratory Medicine, Shanghai First People's Hospital, Shanghai Jiaotong University School of Medicine, 2Department of Pediatrics, BC Children's Hospital and University of British Columbia

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Toll-lignende receptor (TLR) signalering spiller en vigtig rolle i patofysiologien af ​​mange humane inflammatoriske sygdomme, og regulering af TLR-responser af bioaktive nanopartikler forventes at være gavnlig under mange inflammatoriske tilstande. THP-1-cellebaserede reporterceller tilvejebringer en alsidig og robust screeningsplatform til identifikation af nye inhibitorer af TLR-signalering.

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Medicin udgave 125 bioaktive nanopartikler nanodrugs screening guld nanopartikel peptid tolllignende receptor TLR-hæmmer reporterceller
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