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Screening av bioaktive nanopartikler i phagocytiske immunceller for inhibitorer av Toll-lignende Receptor Signalering
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Screening av bioaktive nanopartikler i phagocytiske immunceller for inhibitorer av Toll-lignende Receptor Signalering

Article DOI: 10.3791/56075-v • 09:51 min • July 26th, 2017
July 26th, 2017 •
1, 2, 1, 1, 2
1Department of Respiratory Medicine, Shanghai First People's Hospital, Shanghai Jiaotong University School of Medicine, 2Department of Pediatrics, BC Children's Hospital and University of British Columbia

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Toll-lignende reseptor (TLR) signalering spiller en viktig rolle i patofysiologien til mange humane inflammatoriske sykdommer, og regulering av TLR-responser av bioaktive nanopartikler forventes å være gunstig ved mange inflammatoriske tilstander. THP-1-cellebaserte reporterceller gir en allsidig og robust screeningsplattform for å identifisere nye inhibitorer av TLR-signalering.

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Medisin utgave 125 bioaktive nanopartikler nanoteknisk screening gull nanopartikkel peptid tolllignende reseptor TLR-hemmere reporterceller
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