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Den Murine cholin-mangelfuld, Ethionine-suppleret (CVU) kost Model af kronisk leverskade
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Den Murine cholin-mangelfuld, Ethionine-suppleret (CVU) kost Model af kronisk leverskade

Article DOI: 10.3791/56138-v • 07:28 min • October 21st, 2017
October 21st, 2017 •
1, 1, 2, 3, 1,4, 1, 5,6,7, 8,9, 10,11, 1,12
1School of Biomedical Sciences & Curtin Health Innovation Research Institute, Curtin University, 2School of Public Health & Curtin Health Innovation Research Institute, Curtin University, 3Institute of Biochemistry, Christian-Albrechts-University, 4School of Veterinary and Life Sciences, Murdoch University, 5Centenary Institute of Cancer Medicine and Cell Biology, The University of Sydney, 6Royal Prince Alfred Hospital, 7A.W. Morrow Gastroenterology and Liver Centre, 8QIMR Berghofer Medical Research Institute, 9Faculty of Medicine and Biomedical Sciences, The University of Queensland, 10Fiona Stanley and Fremantle Hospitals, 11School of Medical and Health Sciences, Edith Cowan University, 12School of Medicine and Pharmacology, University of Western Australia

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Her beskriver vi en fælles metode for at fremkalde kronisk leverskade i mus ved fodring med en cholin-mangelfuld og ethionine-suppleret (CVU) kost. Vi demonstrere sundhedsovervågning, leveren perfusion, isolation og bevarelse. Et tidsforløb af seks uger kan informere om leverskade, pathohistology, fibrose, inflammatoriske, og leveren stamfader celle svar.

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Cellebiologi spørgsmålet 128 murine model cholin-mangelfuld ethionine-suppleret kost kronisk leversygdom leveren perfusion lever isoleret leveren stamceller inflammatorisk respons histologi fibrose leveren mikromiljø
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