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Biochemistry

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JoVE Journal Biochemistry
Personalisierte Peptidarrays für die Erkennung von HLA Alloantibodies in Organtransplantation
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Personalisierte Peptidarrays für die Erkennung von HLA Alloantibodies in Organtransplantation

Article DOI: 10.3791/56278-v • 08:07 min • September 6th, 2017
September 6th, 2017 •
1, 1, 1, 3, 2, 1
1Division of Nephrology and Hypertension, and the Center for Kidney Research and Therapeutics at the Feinberg Cardiovascular Research Institute, Northwestern University Feinberg School of Medicine, 2Surgery-Organ Transplantation, Northwestern University Feinberg School of Medicine, 3School of Biological Sciences and Medical Engineering, Southeast University

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Fehlanpassungen in human Leukocyte Antigen (HLA) Sequenzen zwischen Organspender und Empfänger-Paare sind die Hauptursache der Antikörper-vermittelten Ablehnung im Organ-Transplantation. Hier präsentieren wir Ihnen die Verwendung von benutzerdefinierten Antigen-Arrays, die auf einzelnen Spendern HLA Sequenzen, Anti-Spender HLA Alloantibodies in Organempfängern Sonde basieren.

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Biochemie Ausgabe 127 Organtransplantation Antikörper vermittelte Transplantatabstoßung (AMR) Human Leukocyte Antigen (HLA) HLA Missverhältnis Alloantibody Antigen-Array SPOT-Synthese
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