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JoVE Journal Biochemistry
Personalizado do Peptide matrizes para a deteção de aloanticorpos HLA no transplante de órgãos
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Personalizado do Peptide matrizes para a deteção de aloanticorpos HLA no transplante de órgãos

Article DOI: 10.3791/56278-v • 08:07 min • September 6th, 2017
September 6th, 2017 •
1, 1, 1, 3, 2, 1
1Division of Nephrology and Hypertension, and the Center for Kidney Research and Therapeutics at the Feinberg Cardiovascular Research Institute, Northwestern University Feinberg School of Medicine, 2Surgery-Organ Transplantation, Northwestern University Feinberg School of Medicine, 3School of Biological Sciences and Medical Engineering, Southeast University

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Incompatibilidades em sequências de antigénios (HLA) leucocitário humano entre doador e beneficiários pares são a principal causa de rejeição mediada por anticorpo em transplante de órgãos. Aqui nós apresentamos o uso de matrizes de antígeno personalizado com base em sequências HLA dos doadores individuais para sondar aloanticorpos HLA antidoadores em receptores de órgãos.

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Bioquímica edição 127 transplante de órgãos rejeição de transplante de anticorpo mediada (AMR) Antígeno leucocitário humano (HLA) incompatibilidade de HLA Alo-anticorpo antígeno array síntese SPOT
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