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Biochemistry

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JoVE Journal Biochemistry
Gepersonaliseerd Peptide Arrays voor detectie van HLA Alloantibodies in orgaantransplantatie
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Gepersonaliseerd Peptide Arrays voor detectie van HLA Alloantibodies in orgaantransplantatie

Article DOI: 10.3791/56278-v • 08:07 min • September 6th, 2017
September 6th, 2017 •
1, 1, 1, 3, 2, 1
1Division of Nephrology and Hypertension, and the Center for Kidney Research and Therapeutics at the Feinberg Cardiovascular Research Institute, Northwestern University Feinberg School of Medicine, 2Surgery-Organ Transplantation, Northwestern University Feinberg School of Medicine, 3School of Biological Sciences and Medical Engineering, Southeast University

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Incongruenties in menselijke leukocyten antigeen (HLA) sequenties tussen organ donor en ontvanger paren zijn de belangrijkste oorzaak van antilichaam-gemedieerde afwijzing in orgaantransplantatie. Hier presenteren we het gebruik van aangepaste antigeen arrays die zijn gebaseerd op individuele donoren HLA sequenties sonde anti-donor HLA alloantibodies orgel geadresseerden.

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Biochemie kwestie 127 orgaantransplantatie antilichaam gemedieerde transplantatie afwijzing (AMR) Human leukocyte antigeen (HLA) HLA mismatch Alloantibody antigeen array SPOT synthese
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