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Journal / Biochemistry / Personalizzato Peptide matrici per il rilevamento …
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Biochemistry

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JoVE Journal Biochemistry
Personalizzato Peptide matrici per il rilevamento di anticorpi HLA nei trapianti d'organo
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Personalizzato Peptide matrici per il rilevamento di anticorpi HLA nei trapianti d'organo

Article DOI: 10.3791/56278-v • 08:07 min • September 6th, 2017
September 6th, 2017 •
1, 1, 1, 3, 2, 1
1Division of Nephrology and Hypertension, and the Center for Kidney Research and Therapeutics at the Feinberg Cardiovascular Research Institute, Northwestern University Feinberg School of Medicine, 2Surgery-Organ Transplantation, Northwestern University Feinberg School of Medicine, 3School of Biological Sciences and Medical Engineering, Southeast University

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Mancate corrispondenze nelle sequenze (HLA) l'antigene umano del leucocita tra donatore di organi e destinatario coppie sono la principale causa di rigetto anticorpo-mediato nel trapianto dell'organo. Qui presentiamo l'uso di matrici di antigene personalizzati che si basano su sequenze di singoli donatori HLA per sondare gli alloanticorpi di anti-donatori HLA nei destinatari dell'organo.

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Biochimica problema 127 trapianto d'organo rigetto anticorpo mediato (AMR) antigene umano del leucocita (HLA) mancata corrispondenza HLA alloanticorpo antigene array sintesi SPOT
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