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Journal / Biochemistry / Personlig peptid matriser för detektion av HLA…
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Biochemistry

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JoVE Journal Biochemistry
Personlig peptid matriser för detektion av HLA alloantikroppar vid organtransplantation
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Personlig peptid matriser för detektion av HLA alloantikroppar vid organtransplantation

Article DOI: 10.3791/56278-v • 08:07 min • September 6th, 2017
September 6th, 2017 •
1, 1, 1, 3, 2, 1
1Division of Nephrology and Hypertension, and the Center for Kidney Research and Therapeutics at the Feinberg Cardiovascular Research Institute, Northwestern University Feinberg School of Medicine, 2Surgery-Organ Transplantation, Northwestern University Feinberg School of Medicine, 3School of Biological Sciences and Medical Engineering, Southeast University

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Avvikelser i humant leukocyt antigen (HLA) sekvenser mellan organdonator och mottagarens par är den största orsaken för antikroppsmedierad avstötning vid organtransplantation. Här presenterar vi användningen av anpassade antigen matriser som baseras på individuella givarnas HLA sekvenser sond mot givaren HLA alloantikroppar i organ mottagaren.

Tags

Biokemi problemet 127 organtransplantation antikropp medierad transplantatavstötning (AMR) humant leukocytantigen (HLA) HLA mismatch alloantikropp Antigen array fläck syntes
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