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JoVE Journal Cancer Research
En General metode til påvisning af Nitrosamide dannelse i In Vitro metabolismen af nitrosaminer af cytokrom P450s
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En General metode til påvisning af Nitrosamide dannelse i In Vitro metabolismen af nitrosaminer af cytokrom P450s

Article DOI: 10.3791/56312-v • 07:38 min • September 25th, 2017
September 25th, 2017 •
1,2, 2, 2
1Department of Pharmacology, University of Minnesota, 2Masonic Cancer Center, University of Minnesota

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Α-hydroxylering af kræftfremkaldende nitrosaminer af cytokrom P450s er den accepterede stofskiftevej, der producerer DNA-skader mellemprodukter, som forårsager mutationer. Men nye data viser yderligere oxidation til nitrosamides kan forekomme. Vi beskriver en generel metode til påvisning af nitrosamides fremstillet af in vitro- cytokrom P450-katalyseret metabolisme af nitrosaminer.

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Cellebiologi sag 127 Nitrosamin nitrosamide cytokrom P450 stofskifte processive oxidation carcinogenese høj opløsning massespektrometri
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