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JoVE Journal
Immunology and Infection

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Overlappende peptid Bibliotek kortlægge Qa-1 epitoper i et Protein
 
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Overlappende peptid Bibliotek kortlægge Qa-1 epitoper i et Protein

Article DOI: 10.3791/56401-v 08:04 min December 20th, 2017
December 20th, 2017

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Summary

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QA-1 (HLA-E i menneskelige) tilhører en gruppe af ikke-klassisk store histocompatibility komplekse 1b molekyler. Vaccination med Qa-1-bindende epitoper har vist sig at forøge væv-specifik immun regulering og rette op på flere autoimmune sygdomme. Heri beskrives en overlappende peptid bibliotek strategi til identifikation af Qa-1 epitoper i et protein.

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Immunologi spørgsmålet 130 overlappende peptid Qa-1 nonclassical store histocompatibility komplekse HLA-E immun forordning immun overvågning
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