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Journal / Medicine / 持续药物输注系统对小鼠脑内下丘脑胰岛素信号的研究…
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JoVE Journal Medicine
持续药物输注系统对小鼠脑内下丘脑胰岛素信号的研究
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持续药物输注系统对小鼠脑内下丘脑胰岛素信号的研究

Article DOI: 10.3791/56410-v • 08:32 min • January 4th, 2018
January 4th, 2018 •
1,2, 1,2,3
1The Ph.D. Program for Neural Regenerative Medicine, College of Medical Science and Technology, Taipei Medical University and National Health Research, 2Graduate Institute of Neural Regenerative Medicine, College of Medical Science and Technology, Taipei Medical University, 3TMU research center for Neurotrauma and Neuroregeneration, College of Medical Science and Technology, Taipei Medical University

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该协议研究的作用趋化因子 (c-c 主题) 配体 5 (CCL5) 在下丘脑通过提供拮抗剂,满足CCL5, 进入鼠标的大脑使用微渗透泵脑输液系统。这种瞬态抑制 CCL5 活动阻断了下丘脑胰岛素信号, 导致葡萄糖不耐受和外周系统胰岛素敏感性。

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药物 问题 131 脑药物传递 微渗透泵 胰岛素耐受 葡萄糖代谢 趋化因子 (c-c 主题) 配体 5 (CCL5) 2 型糖尿病 (T2DM)
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