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Studere hypothalamus Insulin Signal perifere glukose intoleranse med kontinuerlig narkotika Infusjonssystem inn i musen hjernen
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Studere hypothalamus Insulin Signal perifere glukose intoleranse med kontinuerlig narkotika Infusjonssystem inn i musen hjernen

Article DOI: 10.3791/56410-v • 08:32 min • January 4th, 2018
January 4th, 2018 •
1,2, 1,2,3
1The Ph.D. Program for Neural Regenerative Medicine, College of Medical Science and Technology, Taipei Medical University and National Health Research, 2Graduate Institute of Neural Regenerative Medicine, College of Medical Science and Technology, Taipei Medical University, 3TMU research center for Neurotrauma and Neuroregeneration, College of Medical Science and Technology, Taipei Medical University

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Denne protokollen studier rollen chemokine (C-C motiv) ligand 5 (CCL5) i hypotalamus ved å levere en antagonist, MetCCL5, inn i musen hjernen ved hjelp av en mikro-osmotisk pumpe hjernen infusjonssystemet. Denne forbigående hemming av CCL5 aktivitet avbrutt hypothalamus insulin signalnettverk, som fører til glukose intoleranse og eksterne systemisk insulinfølsomhet.

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Medisin problemet 131 hjernen narkotika-leveranser mikro-osmotisk pumpe insulin toleranse glukose metabolisme chemokine (C-C motiv) ligand 5 (CCL5) type 2 diabetes mellitus (T2DM)
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