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Journal / Medicine / Estudando o sinal de insulina hipotalâmico a…
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Estudando o sinal de insulina hipotalâmico a intolerância de glicose periférica com um sistema de infusão contínua de drogas dentro do cérebro de rato
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Estudando o sinal de insulina hipotalâmico a intolerância de glicose periférica com um sistema de infusão contínua de drogas dentro do cérebro de rato

Article DOI: 10.3791/56410-v • 08:32 min • January 4th, 2018
January 4th, 2018 •
1,2, 1,2,3
1The Ph.D. Program for Neural Regenerative Medicine, College of Medical Science and Technology, Taipei Medical University and National Health Research, 2Graduate Institute of Neural Regenerative Medicine, College of Medical Science and Technology, Taipei Medical University, 3TMU research center for Neurotrauma and Neuroregeneration, College of Medical Science and Technology, Taipei Medical University

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Este protocolo estuda o papel do ligante de chemokine (C-C motif) 5 (CCL5) no hipotálamo, entregando um antagonista, MetCCL5, dentro do cérebro de rato usando um sistema de infusão de cérebro de bomba micro-osmótica. Esta inibição transitória de CCL5 atividade interrompida hipotalâmica insulina sinalização, levando à intolerância à glicose e a sensibilidade periférica à insulina sistêmica.

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Medicina questão 131 cérebro de drogas entrega micro-osmótica bomba tolerância insulina metabolismo da glicose chemokine (C-C motif) ligand 5 (CCL5) diabetes mellitus tipo 2 (T2DM)
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