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JoVE Journal Neuroscience
Om inrättande av en musmodell av en ren liten Fiber neuropati med den Ultrapotent Agonist av Transient Receptor Potential Vanilloid typ 1
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Om inrättande av en musmodell av en ren liten Fiber neuropati med den Ultrapotent Agonist av Transient Receptor Potential Vanilloid typ 1

Article DOI: 10.3791/56651 • 09:39 min
February 13th, 2018 •
1,2, 3, 1,2
1Department of Anatomy, School of Medicine, College of Medicine, Kaohsiung Medical University, 2Department of Medical Research, Kaohsiung Medical University Hospital, 3Department of Medical Research, Ultrastructural Laboratory, Kaohsiung Medical University Hospital

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February 13th, 2018

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Denna studie upprättar en experimentell modell av ren liten fiber neuropati med resiniferatoxin (RTX). En unik dos av RTX (50 µg/kg) är optimal för att utveckla en liten fiber neuropati modell som härmar patientens egenskaper och kan hjälpa till att undersöka nociceptiva molekylär betydelsen bakom neuropatisk smärta.

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