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Sequenciamento de genoma inteiro de Candida glabrata para deteção de marcadores de antifúngicos resistência às drogas
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Sequenciamento de genoma inteiro de Candida glabrata para deteção de marcadores de antifúngicos resistência às drogas

Article DOI: 10.3791/56714-v • 08:46 min • December 28th, 2017
December 28th, 2017 •
*1, *1,2,3, 1,2, 1, 1, 1, 1, 1, 1, 4, 4,5, 6, 7, 1,3, 1,2,3
1Centre for Infectious Diseases and Microbiology-Public Health, Westmead Hospital, 2Centre for Infectious Diseases and Microbiology Laboratory Services, ICPMR, 3Marie Bashir Institute for Infectious Diseases and Biosecurity, The University of Sydney, 4Department of Microbiology and Infectious Diseases, Canberra Hospital and Health Services, Australian National University Medical School, 5Infection Management Services, Australian National University Medical School, 6Department of Microbiology and Infectious Diseases, St. Vincent's Hospital, 7Department of Infectious Diseases, Peter MacCallum Cancer Centre
* These authors contributed equally

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Este estudo implementado sequenciamento do genoma inteiro para análise de mutações em genes que conferem resistência a drogas antifúngicas no Candida glabrata. Isolados de c. glabrata resistentes à echinocandins, azóis e 5-flucitosina, foram sequenciados para ilustrar a metodologia. Perfis de susceptibilidade dos isolados correlacionaram com a presença ou ausência de padrões específicos de mutação nos genes.

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Medicina edição 130 Candida glabrata sequenciamento de genoma inteiro resistência a drogas antifúngicas echinocandins azóis 5-flucitosina genoma-análise ampla
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